Topical mitomycin in endoscopic-assisted probing for the treatment of congenital nasolacrimal duct obstruction in older children

Silvana A. Schellini, Alicia Galindo-Ferreiro. Topical mitomycin in endoscopic-assisted probing for the treatment of congenital nasolacrimal duct obstruction in older children. Arquivos Brasileiros de Oftalmologia, July, 2019.

In this article the intention was to know whether adding local Mitomycin C (MMTC) applied in the inferior meatus at the exit of the nasolacrimal duct in endoscopic-assisted probing could improve the results of probing in older children.

We did a retrospective chart review involving two groups of children aged <12 years old who underwent to endoscopic-assisted probing: 30 with MMCT compared to 38 without MMCT. The MMTC group received 0.2 mgr/ml, 4 min locally at the exit of the nasolacrimal duct immediately after probing. The success rate was very high in both groups, with 100% success in MMTC group and 89.5% with no MMTC (p=0.09). No adverse effect was observed in the inferior meatus in any patient.

The conclusion was MMTC does not improve the success rate of probing in older children. However, the high success rate of the two groups may influence in the analysis. Additionally, there are many bias which may interfere in the results such as type and place of obstruction, and confounders as use of stents or no.

Dr. Silvana Schellini

Ophthalmologist - CRM-SP 41155

Scientific Area

Silvana A. Schellini, Alicia Galindo-Ferreiro. Topical mitomycin in endoscopic-assisted probing for the treatment of congenital nasolacrimal duct obstruction in older children. Arquivos Brasileiros de Oftalmologia, July, 2019.

Dr. Silvana Schellini

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