Osaki T, Osaki MH, Osaki TH, Hirai FE, Nallasamy N, Campos M. Influence of involuntary eyelid spasms on corneal topographic and eyelid morphometric changes in patients with hemifacial spasm. British Journal of Ophthalmology, 2016: 100: 963-70.
In hemifacial spasm patients, treatment relieves eyelid spasms on the affected side. This study aimed to evaluate possible changes in corneal topography and eyelid morphometry during a four-month period (15 days, two, three, and four months) in hemifacial spasm patients treated with botulinum toxin applications. On the affected side, a statistically significant increase in mean palpebral fissure height and interpalpebral surface area was observed 15 days, two, and three months after treatment; a statistically significant decrease in steep K and astigmatism was observed, two and three months after treatment. On the non-affected side, no statistically significant difference was observed after treatment. Our results suggest that treatment with botulinum toxin in patients with hemifacial spasm leads to eyelid and corneal changes on the affected eye that are significant during the known period of action of the toxin. Thus, caution should be taken when performing ophthalmological examination in these patients, since it may vary according to the botulinum toxin period of action.